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MLB DFS 4-22-21 Slate Breakdown



MLB DFS 4-22-21 Advice for Fanduel and DraftKings

Our MLB DFS 4-22-21 Advice for Fanduel and DraftKings Advice can be used for this 8 game slate. FantasyTeamAdvisors is very excited to be able to provide you with some MLB content once again. Let’s dig in!

Make sure to also check out all the Vegas Odds for today’s slate. You can also read more DFS advice and lineup picks for sites like FanDuel, and other sports too. If you have any questions or comments, feel free to hit me up on Twitter @advisors_team




12:35 PM EST : Arizona ( 128 ) at Cincinnati ( -139 ) O/U: 8.5

1:10 PM EST : Pittsburgh ( 111 ) at Detroit ( -121 ) O/U: 8.5

6:10 PM EST : NY Yankees ( -102 ) at Cleveland ( -108 ) O/U: 8.5

7:10 PM EST : Seattle ( 151 ) at Boston ( -164 ) O/U: 9.5

7:40 PM EST : NY Mets ( -126 ) at Chi Cubs ( 116 ) O/U: 9

8:10 PM EST : LA Angels ( 111 ) at Houston ( -120 ) O/U: 9

9:45 PM EST : Miami ( 129 ) at San Francisco ( -140 ) O/U: 8

10:10 PM EST : San Diego ( 160 ) at LA Dodgers ( -175 ) O/U: 8


MLB DFS 4-22-21

As stated in the above video, I really like Hoffman for an early GPP play today. He’s had success against ARI in the past but I just can’t trust him enough for Cash as he isn’t striking out the D-Backs as I would like at only a 19.7% rate. 

MLB DFS 4-22-21

He just got called back up from the Alternate site after struggling for 2 straight starts. He was on FIRE during spring training and the Yankees really need to have some pitching go the distance outside of Cole. Yankees currently are in last in the AL East and things are getting ugly. CLE might be the exact feast the Yankees pitching/hitters need today.

I love Pivetta in this spot if we can get us at least 5 innings and 4-5 Ks. Should pay off the salary quite nicely on both FD and DK today.

He’s coming off a fantastic outing against the Royals where he struck out 10 batters and went above and beyond any projections in that start. This one will be a bit of a harder task as the Astros are obviously a good hitting team so that would push me towards Cobb as a GPP pitcher today.

Love this match-up for Buehler against a team he just shoved against last weekend. Buehler had a terrible ST but has ramped up in his few starts and looks to continue that today.

Honestly, this slate is just not a good cash-game slate really. Sanchez makes us a good GPP pitcher against a Marte-less Marlins’ offense.

Weather To Watch:


No weather concerns as of now. Check the CheatSheet for updates.



On our Cheat Sheet.

We just launched a DraftKings Lineup Optimizer. You can find that here.


Here’s a Look Into Our Bacon Station (This is just an example, it does not update every day)




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Want to see which players we like by position?  Check out our Cheat Sheet.


REMEMBER: These are lineups we use, but feel free to pick and choose plays and make your own lineups. Don’t ALWAYS follow these as they don’t hit 100% of the time. We do use these but sometimes late scratches happen and it’s too late to update the lineup. Good luck and bring home the bacon.


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